PXD050317 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome dynamics of HL-60, NB4, and K562 cells under the ATRA treatment |
| Description | Searching for new strategies of acute myeloid leukemia (AML) treatment is of particular interest. Cell lines, e. g. HL-60 and NB4, represent model systems to study molecular features of leukemic cells. The all-trans-retinoic acid (ATRA) has proven itself to be an effective treatment for one of AML subtypes, i.e., acute promyelocytic leukemia (APL). At the same time, ATRA causes granulocytic differentiation of non-APL leukemic cells in vitro. Combination of new therapeutics with ATRA could improve efficiency of treatment. Studying the proteome perturbation in leukemic cells under the ATRA treatment allows to determine potential regulatory molecules that could be affected pharmacologically. Thus, the TMT-based proteomic profiles of HL-60, NB4, and K562 cell lines under the ATRA treatment were obtained at 0, 3, 12, 24, and 72 h after the ATRA treatment. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-06-23 |
| AnnouncementXML | Submission_2024-06-23_01:49:54.072.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Svetlana Novikova |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-03-04 02:53:54 | ID requested | |
| ⏵ 1 | 2024-06-23 01:49:54 | announced | |
| 2 | 2024-10-22 06:47:06 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.3390/ijms25094618; |
| Novikova S, Tolstova T, Kurbatov L, Farafonova T, Tikhonova O, Soloveva N, Rusanov A, Zgoda V, Systems Biology for Drug Target Discovery in Acute Myeloid Leukemia. Int J Mol Sci, 25(9):(2024) [pubmed] |
Keyword List
| submitter keyword: NB4 cell line, K562 cell line, ATRA, TMT labeling, time-course experiment,HL-60 cell line, proteome |
Contact List
| Victor Zgoda |
|---|
| contact affiliation | Laboratory of Systems Biology,Institute of Biomedical Chemistry, Moscow, Russia |
| contact email | victor.zgoda@gmail.com |
| lab head | |
| Svetlana Novikova |
|---|
| contact affiliation | Institute of Biomedical Bhemistry (IBMC), Moscow |
| contact email | novikova.s.e3101@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD050317 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050317
- Label: PRIDE project
- Name: Proteome dynamics of HL-60, NB4, and K562 cells under the ATRA treatment
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