PXD050260 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The effect of an MLK3-targeting PROTAC on protein levels in model breast cancer cell lines. |
| Description | The objective of the study was to explore how a new compound (CEP1347-VHL-02 PROTAC) which facilitates the breakdown of mitogen-activated protein kinase kinase kinase 11 (MLK3), affects the protein quantities in the total cell extracts from specific breast cancer cell models. The cell lines used in the study (MCF-7, MDA-MB-468, and HCC1806, the last featuring inducible MLK3 expression) underwent treatment with the PROTAC or matched controls. The data is divided into three subsets, each representing results from a distinct cell line. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_07:00:25.549.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Remigiusz Serwa |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-03-01 01:39:09 | ID requested | |
| 1 | 2024-10-02 04:36:20 | announced | |
| ⏵ 2 | 2024-10-22 07:00:25 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: MLK3, CEP1347-VHL-02 PROTAC, HCC1806, MCF-7, MDA-MB-468 |
Contact List
| Anna Marusiak |
|---|
| contact affiliation | Laboratory of Molecular OncoSignalling, IMol Polish Academy of Sciences, Warsaw, Poland |
| contact email | a.marusiak@imol.institute |
| lab head | |
| Remigiusz Serwa |
|---|
| contact affiliation | The International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences |
| contact email | r.serwa@imol.edu.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD050260 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050260
- Label: PRIDE project
- Name: The effect of an MLK3-targeting PROTAC on protein levels in model breast cancer cell lines.
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