PXD050260-1

PXD050260 is an original dataset announced via ProteomeXchange.

Title	The effect of an MLK3-targeting PROTAC on protein levels in model breast cancer cell lines.
Description	The objective of the study was to explore how a new compound (CEP1347-VHL-02 PROTAC) which facilitates the breakdown of mitogen-activated protein kinase kinase kinase 11 (MLK3), affects the protein quantities in the total cell extracts from specific breast cancer cell models. The cell lines used in the study (MCF-7, MDA-MB-468, and HCC1806, the last featuring inducible MLK3 expression) underwent treatment with the PROTAC or matched controls. The data is divided into three subsets, each representing results from a distinct cell line.
HostingRepository	PRIDE
AnnounceDate	2024-10-02
AnnouncementXML	Submission_2024-10-02_04:36:20.014.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Remigiusz Serwa
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-01 01:39:09	ID requested
⏵ 1	2024-10-02 04:36:20	announced
2	2024-10-22 07:00:25	announced	2024-10-22: Updated project metadata.

10.1021/ACS.JMEDCHEM.4C00577;

submitter keyword: MLK3, CEP1347-VHL-02 PROTAC, HCC1806, MCF-7, MDA-MB-468

Anna Marusiak
contact affiliation	Laboratory of Molecular OncoSignalling, IMol Polish Academy of Sciences, Warsaw, Poland
contact email	a.marusiak@imol.institute
lab head
Remigiusz Serwa
contact affiliation	The International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences
contact email	r.serwa@imol.edu.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD050260

PRIDE project URI

• PRIDE
  1. PXD050260
     1. Label: PRIDE project
     2. Name: The effect of an MLK3-targeting PROTAC on protein levels in model breast cancer cell lines.