PXD048447-2

PXD048447 is an original dataset announced via ProteomeXchange.

Title	The Shigella kinase effector OspG hijacks host ubiquitin signaling to escape septin-cage entrapment
Description	We show by unbiased phosphoproteomics that a major target of OspG is CAND1, a regulatory protein controlling the assembly of cullin-RING ubiquitin ligases (CRLs). CAND1 phosphorylation weakens its interaction with cullins, which is expected to impact a large panel of CRL E3s. Indeed, global ubiquitome profiling reveals marked changes in the ubiquitination landscape when OspG is introduced. Notably, OspG promotes ubiquitination of a class of cytoskeletal proteins called septins, thereby inhibiting formation of cage-like structures encircling cytosolic bacteria.
HostingRepository	iProX
AnnounceDate	2024-01-10
AnnouncementXML	Submission_2024-05-09_20:52:28.241.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Xian
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ; LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-11 00:09:43	ID requested
1	2024-01-11 00:10:10	announced
⏵ 2	2024-05-09 20:52:29	announced	2024-05-10: Update information.

Xian W, Fu J, Zhang Q, Li C, Zhao YB, Tang Z, Yuan Y, Wang Y, Zhou Y, Brzoic PS, Zheng N, Ouyang S, Luo ZQ, Liu X, The Shigella kinase effector OspG modulates host ubiquitin signaling to escape septin-cage entrapment. Nat Commun, 15(1):3890(2024) [pubmed]

submitter keyword: Phosphoproteomic, ubiquitome

Xiaoyun Liu
contact affiliation	Peking University Health Science Center
contact email	xiaoyun.liu@bjmu.edu.cn
lab head
Wei Xian
contact affiliation	Peking University Health Science Center
contact email	xianwei@pku.edu.cn
dataset submitter

iProX dataset URI