⮝ Full datasets listing
PXD048447-1
PXD048447 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Shigella kinase effector OspG hijacks host ubiquitin signaling to escape septin-cage entrapment |
| Description | We show by unbiased phosphoproteomics that a major target of OspG is CAND1, a regulatory protein controlling the assembly of cullin-RING ubiquitin ligases (CRLs). CAND1 phosphorylation weakens its interaction with cullins, which is expected to impact a large panel of CRL E3s. Indeed, global ubiquitome profiling reveals marked changes in the ubiquitination landscape when OspG is introduced. Notably, OspG promotes ubiquitination of a class of cytoskeletal proteins called septins, thereby inhibiting formation of cage-like structures encircling cytosolic bacteria. |
| HostingRepository | iProX |
| AnnounceDate | 2024-01-10 |
| AnnouncementXML | Submission_2024-01-11_00:10:10.039.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xian Wei |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | LTQ; LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-01-11 00:09:43 | ID requested | |
| ⏵ 1 | 2024-01-11 00:10:10 | announced | |
| 2 | 2024-05-09 20:52:29 | announced | 2024-05-10: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Phosphoproteomic, ubiquitome |
Contact List
| Xiaoyun Liu | |
|---|---|
| contact affiliation | Peking University Health Science Center |
| contact email | xiaoyun.liu@bjmu.edu.cn |
| lab head | |
| Xian Wei | |
| contact affiliation | Peking University Health Science Center |
| contact email | xianwei@pku.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
