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PXD048447-1

PXD048447 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The Shigella kinase effector OspG hijacks host ubiquitin signaling to escape septin-cage entrapment
Description	We show by unbiased phosphoproteomics that a major target of OspG is CAND1, a regulatory protein controlling the assembly of cullin-RING ubiquitin ligases (CRLs). CAND1 phosphorylation weakens its interaction with cullins, which is expected to impact a large panel of CRL E3s. Indeed, global ubiquitome profiling reveals marked changes in the ubiquitination landscape when OspG is introduced. Notably, OspG promotes ubiquitination of a class of cytoskeletal proteins called septins, thereby inhibiting formation of cage-like structures encircling cytosolic bacteria.
HostingRepository	iProX
AnnounceDate	2024-01-10
AnnouncementXML	Submission_2024-01-11_00:10:10.039.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xian Wei
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ; LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-11 00:09:43	ID requested
⏵ 1	2024-01-11 00:10:10	announced
2	2024-05-09 20:52:29	announced	2024-05-10: Update information.

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Phosphoproteomic, ubiquitome

Contact List

Xiaoyun Liu
contact affiliation	Peking University Health Science Center
contact email	xiaoyun.liu@bjmu.edu.cn
lab head
Xian Wei
contact affiliation	Peking University Health Science Center
contact email	xianwei@pku.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI