PXD047161 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication |
| Description | African swine fever virus (ASFV) has caused severe consequences for the global pig industry. In this study, we conducted a multi-organ proteomic analysis using a 4D label-free quantitative proteomics approach and mapped the organ-specific proteomic landscape during ASFV infection. This work overcomes the limitations of most existing studies, which are primarily restricted to in vitro cell models, and providesprovide a more comprehensive understanding of ASFV infection and pathogenesis. Notably, the viral D117L protein is identified as a critical modulator of host cellular responses, directly subverting the unfolded protein response (UPR) pathway through specific interactions with host UPR-associated proteins. Collectively, our work lays the foundation for understanding the pathogenesis of ASFV, providing potential therapeutic strategies against African swine fever (ASF). |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-28 |
| AnnouncementXML | Submission_2025-11-28_01:54:16.854.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | baohong Liu |
| SpeciesList | scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-11-22 03:00:23 | ID requested | |
| 1 | 2025-11-27 20:02:06 | announced | |
| ⏵ 2 | 2025-11-28 01:54:17 | announced | 2025-11-28: Updated project metadata. |
Publication List
Keyword List
Contact List
| Haixue Zheng |
|---|
| contact affiliation | State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China |
| contact email | zhenghaixue@caas.cn |
| lab head | |
| baohong Liu |
|---|
| contact affiliation | lanzhou veterinary research institute |
| contact email | liubaohong@caas.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD047161 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047161
- Label: PRIDE project
- Name: Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication
