PXD047161-1

PXD047161 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opte Proteomic Analysis Identifies the Unfolded Protein Response as a Host Pathway Co-Opted by ASFV to promote repl Promote Replication
Description	African swine fever virus (ASFV) has caused severe consequences for the global pig industry. In this study, we conducted a multi-organ proteomic analysis using a 4D label-free quantitative proteomics approach and mapped the organ-specific proteomic landscape during ASFV infection. This work overcomes the limitations of most existing studies, which are primarily restricted to in vitro cell models, and providesprovide a more comprehensive understanding of ASFV infection and pathogenesis. Notably, the viral D117L protein is identified as a critical modulator of host cellular responses, directly subverting the unfolded protein response (UPR) pathway through specific interactions with host UPR-associated proteins. Collectively, our work lays the foundation for understanding the pathogenesis of ASFV, providing potential therapeutic strategies against African swine fever (ASF).
HostingRepository	PRIDE
AnnounceDate	2025-11-28
AnnouncementXML	Submission_2025-11-27_20:02:06.354.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	baohong Liu
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-22 03:00:23	ID requested
⏵ 1	2025-11-27 20:02:06	announced
2	2025-11-28 01:54:17	announced	2025-11-28: Updated project metadata.

10.1128/MBIO.03242-25;

submitter keyword: None

Haixue Zheng
contact affiliation	State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
contact email	zhenghaixue@caas.cn
lab head
baohong Liu
contact affiliation	lanzhou veterinary research institute
contact email	liubaohong@caas.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD047161

PRIDE project URI

• PRIDE
  1. PXD047161
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opte Proteomic Analysis Identifies the Unfolded Protein Response as a Host Pathway Co-Opted by ASFV to promote repl Promote Replication