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PXD046525-2

PXD046525 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTNFα conditional knockout promotes myoblasts proliferation, differentiation and muscle regeneration
DescriptionTNFα is a cytokine with multiple biological effects. It activates cascading signal pathways by binding to receptors on the cell membrane, regulating processes such as cell growth, differentiation, apoptosis, and inflammatory responses. The formation of skeletal muscle primarily relies on processes such as myoblasts proliferation, migration, differentiation, cytoskeletal rearrangement, and myotube fusion, which constitute a complex and coordinated process regulated by multiple genes. While research on TNFα has primarily focused on immunology, some studies suggest that TNFα also plays a physiological role in myogenesis, muscle repair, diseases, and atrophy.We isolated the nuclei (N) and cytoplasm (C) of flox and TNFα-CKO primary myoblasts in the early stages of differentiation and attempted to identify new targets in the TNFα signaling pathway.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:53:54.971.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXin Hao
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-31 03:36:25ID requested
12024-08-09 05:25:59announced
22024-10-22 06:53:57announced2024-10-22: Updated project metadata.
Publication List
Fu Y, Nie JR, Shang P, Zhang B, Yan DW, Hao X, Zhang H, deficiency promotes myogenesis and muscle regeneration. Zool Res, 45(4):951-960(2024) [pubmed]
10.24272/j.issn.2095-8137.2024.039;
Keyword List
submitter keyword: Nucleus-cytoplasmic protein separation,TNFα, myogenesis, muscle-specific knockout
Contact List
Xin Hao
contact affiliationChina Agricultural University
contact emailhaoxin0331@163.com
lab head
Xin Hao
contact affiliationChina Agricultural University
contact emailhaoxin0331@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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