PXD046525-2
PXD046525 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TNFα conditional knockout promotes myoblasts proliferation, differentiation and muscle regeneration |
| Description | TNFα is a cytokine with multiple biological effects. It activates cascading signal pathways by binding to receptors on the cell membrane, regulating processes such as cell growth, differentiation, apoptosis, and inflammatory responses. The formation of skeletal muscle primarily relies on processes such as myoblasts proliferation, migration, differentiation, cytoskeletal rearrangement, and myotube fusion, which constitute a complex and coordinated process regulated by multiple genes. While research on TNFα has primarily focused on immunology, some studies suggest that TNFα also plays a physiological role in myogenesis, muscle repair, diseases, and atrophy.We isolated the nuclei (N) and cytoplasm (C) of flox and TNFα-CKO primary myoblasts in the early stages of differentiation and attempted to identify new targets in the TNFα signaling pathway. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_06:53:54.971.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xin Hao |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-10-31 03:36:25 | ID requested | |
| 1 | 2024-08-09 05:25:59 | announced | |
| ⏵ 2 | 2024-10-22 06:53:57 | announced | 2024-10-22: Updated project metadata. |
Publication List
| Fu Y, Nie JR, Shang P, Zhang B, Yan DW, Hao X, Zhang H, deficiency promotes myogenesis and muscle regeneration. Zool Res, 45(4):951-960(2024) [pubmed] |
| 10.24272/j.issn.2095-8137.2024.039; |
Keyword List
| submitter keyword: Nucleus-cytoplasmic protein separation,TNFα, myogenesis, muscle-specific knockout |
Contact List
| Xin Hao | |
|---|---|
| contact affiliation | China Agricultural University |
| contact email | haoxin0331@163.com |
| lab head | |
| Xin Hao | |
| contact affiliation | China Agricultural University |
| contact email | haoxin0331@163.com |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD046525 |
| PRIDE project URI |
Repository Record List
[ + ]
to receive all new ProteomeXchange dataset release announcements!
