PXD046525-1

PXD046525 is an original dataset announced via ProteomeXchange.

Title	TNFα conditional knockout promotes myoblasts proliferation, differentiation and muscle regeneration
Description	TNFα is a cytokine with multiple biological effects. It activates cascading signal pathways by binding to receptors on the cell membrane, regulating processes such as cell growth, differentiation, apoptosis, and inflammatory responses. The formation of skeletal muscle primarily relies on processes such as myoblasts proliferation, migration, differentiation, cytoskeletal rearrangement, and myotube fusion, which constitute a complex and coordinated process regulated by multiple genes. While research on TNFα has primarily focused on immunology, some studies suggest that TNFα also plays a physiological role in myogenesis, muscle repair, diseases, and atrophy.We isolated the nuclei (N) and cytoplasm (C) of flox and TNFα-CKO primary myoblasts in the early stages of differentiation and attempted to identify new targets in the TNFα signaling pathway.
HostingRepository	PRIDE
AnnounceDate	2024-08-09
AnnouncementXML	Submission_2024-08-09_05:25:59.044.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Hao
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-31 03:36:25	ID requested
⏵ 1	2024-08-09 05:25:59	announced
2	2024-10-22 06:53:57	announced	2024-10-22: Updated project metadata.

Fu Y, Nie JR, Shang P, Zhang B, Yan DW, Hao X, Zhang H, deficiency promotes myogenesis and muscle regeneration. Zool Res, 45(4):951-960(2024) [pubmed]

10.24272/j.issn.2095-8137.2024.039;

submitter keyword: Nucleus-cytoplasmic protein separation,TNFα, myogenesis, muscle-specific knockout

Xin Hao
contact affiliation	China Agricultural University
contact email	haoxin0331@163.com
lab head
Xin Hao
contact affiliation	China Agricultural University
contact email	haoxin0331@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD046525

PRIDE project URI

• PRIDE
  1. PXD046525
     1. Label: PRIDE project
     2. Name: TNFα conditional knockout promotes myoblasts proliferation, differentiation and muscle regeneration