PXD046492-2
PXD046492 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A Comprehensive Proteomics Analysis Reveals Dynamic Phenotypes of Tumor-associated Macrophages and Their Precursor Cells in Tumor Progression |
| Description | Tumor-associated macrophages (TAMs) are key regulators in tumor progression. Although a role of bone marrow-derived monocytes (Mons) as TAM precursors has been revealed, the dynamic phenotypes of both TAMs and Mons regulated by the tumor microenvironment remain unclear. Here, we constructed an optimized micro-proteomics workflow, which was applicable to the mouse myeloid cells of low cell number. We sorted both TAMs and the corresponding Mons (1×105 per sample) from individual melanoma mouse model in the early stage and the late stage to establish the protein expression profiles by mass spectrum. |
| HostingRepository | iProX |
| AnnounceDate | 2023-10-30 |
| AnnouncementXML | Submission_2024-05-20_20:14:23.586.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuchen Liu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-10-30 01:31:04 | ID requested | |
| 1 | 2023-10-30 21:06:37 | announced | |
| 1 | 2023-10-30 21:06:37 | announced | |
| ⏵ 2 | 2024-05-20 20:14:24 | announced | 2024-05-21: Update information. |
Publication List
| Liu Y, Liu D, Liu Y, Fu B, Ji S, Wang R, Yan F, Wang H, Zhao D, Yang W, Wang J, Tang L, Comprehensive Proteomics Analysis Reveals Dynamic Phenotypes of Tumor-Associated Macrophages and Their Precursor Cells in Tumor Progression. J Proteome Res, 23(2):822-833(2024) [pubmed] |
Keyword List
| submitter keyword: tumor-associated macrophages, bone marrow-derived monocyte, proteomics, tumor progression |
Contact List
| Jian Wang | |
|---|---|
| contact affiliation | State Key Laboratory of Proteomics, Beijing Proteome Research Center |
| contact email | wangjian@bmi.ac.cn |
| lab head | |
| Yuchen Liu | |
| contact affiliation | State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences· Beijing, Beijing Institute of Lifeomics, Beijing, China. |
| contact email | 57994893@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
