PXD046492-1

PXD046492 is an original dataset announced via ProteomeXchange.

Title	A Comprehensive Proteomics Analysis Reveals Dynamic Phenotypes of Tumor-associated Macrophages and Their Precursor Cells in Tumor Progression
Description	Tumor-associated macrophages (TAMs) are key regulators in tumor progression. Although a role of bone marrow-derived monocytes (Mons) as TAM precursors has been revealed, the dynamic phenotypes of both TAMs and Mons regulated by the tumor microenvironment remain unclear. Here, we constructed an optimized micro-proteomics workflow, which was applicable to the mouse myeloid cells of low cell number. We sorted both TAMs and the corresponding Mons (1×105 per sample) from individual melanoma mouse model in the early stage and the late stage to establish the protein expression profiles by mass spectrum.
HostingRepository	iProX
AnnounceDate	2023-10-30
AnnouncementXML	Submission_2023-10-30_21:06:37.214.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuchen Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-30 01:31:04	ID requested
⏵ 1	2023-10-30 21:06:37	announced
⏵ 1	2023-10-30 21:06:37	announced
2	2024-05-20 20:14:24	announced	2024-05-21: Update information.

Dataset with its publication pending

submitter keyword: tumor-associated macrophages, bone marrow-derived monocyte, proteomics, tumor progression

Jian Wang
contact affiliation	State Key Laboratory of Proteomics, Beijing Proteome Research Center
contact email	wangjian@bmi.ac.cn
lab head
Yuchen Liu
contact affiliation	State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences· Beijing, Beijing Institute of Lifeomics, Beijing, China.
contact email	57994893@qq.com
dataset submitter

iProX dataset URI