PXD046237-2

PXD046237 is an original dataset announced via ProteomeXchange.

Title	Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
Description	Antibodies are immune glycoproteins that represent a crucial part of the adaptive immune system as they mediate broad protection against viruses, bacteria, and cancer. Moreover, antibodies may serve as a unique source of information on past and current physiological and pathological events in the human body. The dysregulation of the antibody-dependent response can lead to a variety of abnormalities and diseases. Antibodies are found in the secreted form in the blood (antibody phenotype) and membrane-bound on B cells as B-cell receptor (antibody genotype). Thus, investigating the relationship between genomic and phenotypic antibody diversity is of decisive importance for understanding antibody-driven immune protection and disease. In this project, we aim to establish a robust high-throughput framework for single-cell (SC) genomic and proteomic characterization of antibody repertoires using high-throughput genomic sequencing and mass spectrometry. The generated data will be analyzed using a variety of bioinformatics tools.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:43:44.309.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Khang Le Quy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-19 04:55:42	ID requested
1	2024-06-04 10:03:32	announced
⏵ 2	2024-10-22 06:43:44	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Human, LC-MSMS, Plasma, Antibody

Victor Greiff
contact affiliation	Department of Immunology - Instutue of Clinical Medicine - Faculty of Medicine - University of Oslo, Norway
contact email	victor.greiff@medisin.uio.no
lab head
Khang Le Quy
contact affiliation	University of Oslo
contact email	q.k.le@medisin.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD046237

PRIDE project URI

• PRIDE
  1. PXD046237
     1. Label: PRIDE project
     2. Name: Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling