PXD046237 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling |
Description | Antibodies are immune glycoproteins that represent a crucial part of the adaptive immune system as they mediate broad protection against viruses, bacteria, and cancer. Moreover, antibodies may serve as a unique source of information on past and current physiological and pathological events in the human body. The dysregulation of the antibody-dependent response can lead to a variety of abnormalities and diseases. Antibodies are found in the secreted form in the blood (antibody phenotype) and membrane-bound on B cells as B-cell receptor (antibody genotype). Thus, investigating the relationship between genomic and phenotypic antibody diversity is of decisive importance for understanding antibody-driven immune protection and disease. In this project, we aim to establish a robust high-throughput framework for single-cell (SC) genomic and proteomic characterization of antibody repertoires using high-throughput genomic sequencing and mass spectrometry. The generated data will be analyzed using a variety of bioinformatics tools. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-04 |
AnnouncementXML | Submission_2024-06-04_10:03:32.366.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Khang Le Quy |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-19 04:55:42 | ID requested | |
⏵ 1 | 2024-06-04 10:03:32 | announced | |
2 | 2024-10-22 06:43:44 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, LC-MSMS, Plasma, Antibody |
Contact List
Victor Greiff |
contact affiliation | Department of Immunology - Instutue of Clinical Medicine - Faculty of Medicine - University of Oslo, Norway |
contact email | victor.greiff@medisin.uio.no |
lab head | |
Khang Le Quy |
contact affiliation | University of Oslo |
contact email | q.k.le@medisin.uio.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD046237 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046237
- Label: PRIDE project
- Name: Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling