<<< Full experiment listing

PXD046237-1

PXD046237 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBenchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
DescriptionAntibodies are immune glycoproteins that represent a crucial part of the adaptive immune system as they mediate broad protection against viruses, bacteria, and cancer. Moreover, antibodies may serve as a unique source of information on past and current physiological and pathological events in the human body. The dysregulation of the antibody-dependent response can lead to a variety of abnormalities and diseases. Antibodies are found in the secreted form in the blood (antibody phenotype) and membrane-bound on B cells as B-cell receptor (antibody genotype). Thus, investigating the relationship between genomic and phenotypic antibody diversity is of decisive importance for understanding antibody-driven immune protection and disease. In this project, we aim to establish a robust high-throughput framework for single-cell (SC) genomic and proteomic characterization of antibody repertoires using high-throughput genomic sequencing and mass spectrometry. The generated data will be analyzed using a variety of bioinformatics tools.
HostingRepositoryPRIDE
AnnounceDate2024-06-04
AnnouncementXMLSubmission_2024-06-04_10:03:32.366.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKhang Le Quy
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-19 04:55:42ID requested
12024-06-04 10:03:32announced
22024-10-22 06:43:44announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, LC-MSMS, Plasma, Antibody
Contact List
Victor Greiff
contact affiliationDepartment of Immunology - Instutue of Clinical Medicine - Faculty of Medicine - University of Oslo, Norway
contact emailvictor.greiff@medisin.uio.no
lab head
Khang Le Quy
contact affiliationUniversity of Oslo
contact emailq.k.le@medisin.uio.no
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD046237
PRIDE project URI
Repository Record List
[ + ]