PXD045972-1

PXD045972 is an original dataset announced via ProteomeXchange.

Title	Chemical Sensors Detect and Resolve Proteome Aggregation in Peripheral Neuropathy induced by Chemotherapeutic Agents
Description	Neuropathic pain, a consequence of somatosensory nervous system injury or disease, is commonly associated with cancer and its treatments, including chemotherapy-induced peripheral neuropathy (CIPN). However, the mechanisms underlying CIPN-induced proteome aggregation remain elusive due to limited detection tools. Here, we present a combined approach employing fluorescence imaging and proteomic sensors to comprehensively study proteome aggregation in neuronal cells subjected to CIPN. The AggStain imaging probe sensitively detected proteome aggregation, while the AggLink proteomic sensor captured and profiled aggregated proteins. This integrative sensor system offers novel insights into proteome aggregation dynamics in CIPN and highlights its potential for broader applications in assessing proteome stability under various conditions.
HostingRepository	iProX
AnnounceDate	2023-10-09
AnnouncementXML	Submission_2023-10-08_19:46:47.733.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhiming Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-08 19:46:38	ID requested
⏵ 1	2023-10-08 19:46:48	announced

Dataset with its publication pending

submitter keyword: Protein aggregation

Proteomics

Peripheral neuropathy

Chemotherapy.

Zhiming Wang
contact affiliation	The Second Hospital of Dalian Medical University
contact email	1449619597@qq.com
lab head
Zhiming Wang
contact affiliation	The Second Hospital of Dalian Medical University
contact email	1449619597@qq.com
dataset submitter

iProX dataset URI