<<< Full experiment listing


PXD045477 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium
DescriptionBidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we showed that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Lin28b in cancer-associated fibroblasts (CAFs). Moreover, we demonstrated that Lin28b in CAFs promoted growth of PDAC by inducing cytokine PCSK9’s production. Using an orthotopic mouse model of PDAC, we fouind that depletion of Lin28b in CAFs reduced tumor weight, highlighting the importance of Lin28b in PDAC stromal. Thus, our study shows that the Lin28b-Wnt5a axis plays a critical role in bidirectional crosstalk between pancreatic tumor epithelium and TME and results in a pro-‍tumorigenic contexture.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZhaoqi Shu
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-18 23:00:43ID requested
12023-09-18 23:00:58announced
22023-12-04 21:04:18announced2023-12-05: Update publication information.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: cancer-associated fibroblasts (CAFs), pancreatic ductal adenocarcinoma (PDAC), Lin28b, Wnt5a, Pcsk9
Contact List
Ying Zhao
contact affiliationPeking University
contact emailzhaoying0812@bjmu.edu.cn
lab head
Zhaoqi Shu
contact affiliationPeking University
contact email443060358@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI