PXD045278-1

PXD045278 is an original dataset announced via ProteomeXchange.

Title	Serum proteome signatures associated with ileal and colonic ulcers in Crohn's disease
Description	At a clinical level, ileal and colonic Crohn's disease (CD) are considered as separate entities. These subphenotypes need to be better supported by biological data to develop personalised medicine in CD. To this end, we combined different technologies (proximity extension assay, selected reaction monitoring, and high-sensitivity turbidimetric immunoassay (hsCRP)) to measure 207 immune-related serum proteins in CD patients presenting no endoscopic lesions (endoscopic remission) (n = 23), isolated ileal ulcers (n = 17), or isolated colonic ulcers (n = 16). We showed that isolated ileal ulcers and isolated colonic ulcers were specifically associated with 6 and 18 serum proteins, respectively: (high level: JUN, CNTNAP2; low level: FCRL6, LTA, CLEC4A, NTF4); (high level: hsCRP, IL6, APCS, CFB, MBL2, IL7, IL17A, CCL19, CXCL10, CSF3, IL10, CLEC4G, MMP12, VEGFA; low level: CLEC3B, GSN, TNFSF12, TPSAB1). Isolated ileal ulcers and isolated colonic ulcers were detected by hsCRP with an area under the receiver operating characteristics curve of 0.64 (p-value = 0.07) and 0.77 (p-value = 0.001), respectively. We highlighted distinct serum proteome profiles associated with ileal and colonic ulcers in CD, this finding might support the development of therapeutics and biomarkers tailored to disease location.
HostingRepository	PanoramaPublic
AnnounceDate	2024-05-17
AnnouncementXML	Submission_2024-05-17_16:11:34.697.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicolas Pierre
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4); Label:13C(6)15N(1)
Instrument	Xevo TQ-S

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-11 14:17:33	ID requested
⏵ 1	2024-05-17 16:11:35	announced

N. Pierre, V.A. Huynh-Thu, D. Baiwir, et al., Serum proteome signatures associated with ileal and colonic ulcers in Crohn's disease, Journal of Proteomics (2023), https://doi.org/10.1016/j.jprot.2024.105199

submitter keyword: Crohn’s disease, disease location, serum proteomics

Edouard Louis
contact affiliation	Laboratory of Translational Gastroenterology, GIGA-institute, University of Liege, Liege, Belgium
contact email	edouard.louis@uliege.be
lab head
Nicolas Pierre
contact affiliation	Laboratory of Translational Gastroenterology, GIGA-institute, University of Liege, Liege, Belgium
contact email	nicolas.pierre@uliege.be
dataset submitter

Panorama Public dataset URI