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PXD045278-1

PXD045278 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSerum proteome signatures associated with ileal and colonic ulcers in Crohn's disease
DescriptionAt a clinical level, ileal and colonic Crohn's disease (CD) are considered as separate entities. These subphenotypes need to be better supported by biological data to develop personalised medicine in CD. To this end, we combined different technologies (proximity extension assay, selected reaction monitoring, and high-sensitivity turbidimetric immunoassay (hsCRP)) to measure 207 immune-related serum proteins in CD patients presenting no endoscopic lesions (endoscopic remission) (n = 23), isolated ileal ulcers (n = 17), or isolated colonic ulcers (n = 16). We showed that isolated ileal ulcers and isolated colonic ulcers were specifically associated with 6 and 18 serum proteins, respectively: (high level: JUN, CNTNAP2; low level: FCRL6, LTA, CLEC4A, NTF4); (high level: hsCRP, IL6, APCS, CFB, MBL2, IL7, IL17A, CCL19, CXCL10, CSF3, IL10, CLEC4G, MMP12, VEGFA; low level: CLEC3B, GSN, TNFSF12, TPSAB1). Isolated ileal ulcers and isolated colonic ulcers were detected by hsCRP with an area under the receiver operating characteristics curve of 0.64 (p-value = 0.07) and 0.77 (p-value = 0.001), respectively. We highlighted distinct serum proteome profiles associated with ileal and colonic ulcers in CD, this finding might support the development of therapeutics and biomarkers tailored to disease location.
HostingRepositoryPanoramaPublic
AnnounceDate2024-05-17
AnnouncementXMLSubmission_2024-05-17_16:11:34.697.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterNicolas Pierre
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListCarbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4); Label:13C(6)15N(1)
InstrumentXevo TQ-S
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-11 14:17:33ID requested
12024-05-17 16:11:35announced
Publication List
N. Pierre, V.A. Huynh-Thu, D. Baiwir, et al., Serum proteome signatures associated with ileal and colonic ulcers in Crohn's disease, Journal of Proteomics (2023), https://doi.org/10.1016/j.jprot.2024.105199
Keyword List
submitter keyword: Crohn’s disease, disease location, serum proteomics
Contact List
Edouard Louis
contact affiliationLaboratory of Translational Gastroenterology, GIGA-institute, University of Liege, Liege, Belgium
contact emailedouard.louis@uliege.be
lab head
Nicolas Pierre
contact affiliationLaboratory of Translational Gastroenterology, GIGA-institute, University of Liege, Liege, Belgium
contact emailnicolas.pierre@uliege.be
dataset submitter
Full Dataset Link List
Panorama Public dataset URI