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<DatasetSummary announceDate="2024-05-17" hostingRepository="PanoramaPublic" title="Serum proteome signatures associated with ileal and colonic ulcers in Crohn's disease">
<Description>At a clinical level, ileal and colonic Crohn's disease (CD) are considered as separate entities. These subphenotypes need to be better supported by biological data to develop personalised medicine in CD. To this end, we combined different technologies (proximity extension assay, selected reaction monitoring, and high-sensitivity turbidimetric immunoassay (hsCRP)) to measure 207 immune-related serum proteins in CD patients presenting no endoscopic lesions (endoscopic remission) (n = 23), isolated ileal ulcers (n = 17), or isolated colonic ulcers (n = 16). We showed that isolated ileal ulcers and isolated colonic ulcers were specifically associated with 6 and 18 serum proteins, respectively: (high level: JUN, CNTNAP2; low level: FCRL6, LTA, CLEC4A, NTF4); (high level: hsCRP, IL6, APCS, CFB, MBL2, IL7, IL17A, CCL19, CXCL10, CSF3, IL10, CLEC4G, MMP12, VEGFA; low level: CLEC3B, GSN, TNFSF12, TPSAB1). Isolated ileal ulcers and isolated colonic ulcers were detected by hsCRP with an area under the receiver operating characteristics curve of 0.64 (p-value = 0.07) and 0.77 (p-value = 0.001), respectively. We highlighted distinct serum proteome profiles associated with ileal and colonic ulcers in CD, this finding might support the development of therapeutics and biomarkers tailored to disease location.</Description>
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<cvParam cvRef="MS" accession="MS:1001919" name="ProteomeXchange accession number" value="PXD045278"/>
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<cvParam cvRef="MS" accession="MS:1001469" name="taxonomy: scientific name" value="Homo sapiens"/>
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<Contact id="lab_head">
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<cvParam cvRef="MS" accession="MS:1000586" name="contact name" value="Edouard Louis"/>
<cvParam cvRef="MS" accession="MS:1000589" name="contact email" value="edouard.louis@uliege.be"/>
<cvParam cvRef="MS" accession="MS:1000590" name="contact affiliation" value="Laboratory of Translational Gastroenterology, GIGA-institute, University of Liege, Liege, Belgium"/>
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<cvParam cvRef="MS" accession="MS:1000586" name="contact name" value="Nicolas Pierre"/>
<cvParam cvRef="MS" accession="MS:1000589" name="contact email" value="nicolas.pierre@uliege.be"/>
<cvParam cvRef="MS" accession="MS:1000590" name="contact affiliation" value="Laboratory of Translational Gastroenterology, GIGA-institute, University of Liege, Liege, Belgium"/>
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<cvParam cvRef="MS" accession="MS:1002866" name="Reference" value="N. Pierre, V.A. Huynh-Thu, D. Baiwir, et al., Serum proteome
signatures associated with ileal and colonic ulcers in Crohn's disease, Journal of
Proteomics (2023), https://doi.org/10.1016/j.jprot.2024.105199"/>
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<cvParam cvRef="MS" accession="MS:1001925" name="submitter keyword" value="serum proteomics"/>
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