PXD044920-2
PXD044920 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of chronic skin wounds in diabetic mice following electrical stimulation therapy delivered by a novel electrostimulation-hydrogel wound dressing |
| Description | In this study, we established a type 2 diabetes model in C57BL/6 mice through high-fat diet induction and STZ injection. Based on this animal model, we simulated clinically common hard-to-heal chronic diabetic skin wounds by implanting a mixed bacterial fluid, including Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PAO1). We treated these wounds with a novel wearable photovoltaic cell-MEMS electrode-hydrogel dressing (PMH dressing), with commercially available Tegaderm film serving as a control, to explore the therapeutic effects of electrical stimulation on chronic wounds. After 22 days of treatment, we collected wound tissues from each group and conducted proteomic studies using nano LC-MS/MS technology in data independent acquisition (DIA) mode. This project is a repeat study of project PXD040252 after experimental condition optimization, and serves as revision data for the manuscript. |
| HostingRepository | iProX |
| AnnounceDate | 2023-08-29 |
| AnnouncementXML | Submission_2024-01-11_18:41:43.233.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yiwei Hu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-08-28 20:28:22 | ID requested | |
| 1 | 2023-08-28 20:28:42 | announced | |
| ⏵ 2 | 2024-01-11 18:41:45 | announced | 2024-01-12: Update publication information. |
Publication List
| Hu YW, Wang YH, Yang F, Liu DX, Lu GH, Li ST, Wei ZX, Shen X, Jiang ZD, Zhao YF, Pang Q, Song BY, Shi ZW, Shafique S, Zhou K, Chen XL, Su WM, Jian JW, Tang KQ, Liu TL, Zhu YB, Flexible Organic Photovoltaic-Powered Hydrogel Bioelectronic Dressing With Biomimetic Electrical Stimulation for Healing Infected Diabetic Wounds. Adv Sci (Weinh), 11(10):e2307746(2024) [pubmed] |
Keyword List
| submitter keyword: Diabetic wound healing, Bacterial infection, Skin wound, Electrical stimulation, Bioelectronics, Hydrogel |
Contact List
| Yuheng Wang | |
|---|---|
| contact affiliation | Ningbo University |
| contact email | nano.plasma.uv@gmail.com |
| lab head | |
| Yiwei Hu | |
| contact affiliation | Ningbo University |
| contact email | scholar.yiwei@outlook.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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