PXD044920-1
PXD044920 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of chronic skin wounds in diabetic mice following electrical stimulation therapy delivered by a novel electrostimulation-hydrogel wound dressing |
| Description | In this study, we established a type 2 diabetes model in C57BL/6 mice through high-fat diet induction and STZ injection. Based on this animal model, we simulated clinically common hard-to-heal chronic diabetic skin wounds by implanting a mixed bacterial fluid, including Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PAO1). We treated these wounds with a novel wearable photovoltaic cell-MEMS electrode-hydrogel dressing (PMH dressing), with commercially available Tegaderm film serving as a control, to explore the therapeutic effects of electrical stimulation on chronic wounds. After 22 days of treatment, we collected wound tissues from each group and conducted proteomic studies using nano LC-MS/MS technology in data independent acquisition (DIA) mode. This project is a repeat study of project PXD040252 after experimental condition optimization, and serves as revision data for the manuscript. |
| HostingRepository | iProX |
| AnnounceDate | 2023-08-29 |
| AnnouncementXML | Submission_2023-08-28_20:28:42.240.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yiwei Hu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-08-28 20:28:22 | ID requested | |
| ⏵ 1 | 2023-08-28 20:28:42 | announced | |
| 2 | 2024-01-11 18:41:45 | announced | 2024-01-12: Update publication information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Diabetic wound healing, Bacterial infection, Skin wound, Electrical stimulation, Bioelectronics, Hydrogel |
Contact List
| Yuheng Wang | |
|---|---|
| contact affiliation | Ningbo University |
| contact email | nano.plasma.uv@gmail.com |
| lab head | |
| Yiwei Hu | |
| contact affiliation | Ningbo University |
| contact email | scholar.yiwei@outlook.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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