PXD044343-2

PXD044343 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis in the TcMAC21 mouse model of Down syndrome
Description	Down syndrome (DS) results from trisomy of human chromosome 21 (HSA21), and DS research has been greatly advanced by the use of mouse models. We previously generated a humanized mouse model of DS, TcMAC21, which carries the long arm of HSA21. These mice exhibit learning and memory deficits, and may reproduce neurodevelopmental alterations observed in humans with DS. Here we performed histologic studies of the TcMAC21 forebrain from embryonic to adult stages. The TcMAC21 neocortex showed reduced proliferation of neural progenitors and delayed neurogenesis. These abnormalities were associated with a smaller number of projection neurons and interneurons. Further, (phospho-)proteomic analysis of adult TcMAC21 cortex revealed alterations in the phosphorylation levels of a series of synaptic proteins. The TcMAC21 mouse model shows similar brain development abnormalities as DS, and will be a valuable mode to investigate prenatal and postnatal causes of intellectual disability in humans with DS.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:06:55.036.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hikari Yoshitane
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-03 23:52:16	ID requested
1	2023-10-22 23:35:37	announced
⏵ 2	2024-10-22 06:06:55	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: LC-MSMS, Down syndrome, phospho-proteome,TcMAC21

Hikari Yoshitane
contact affiliation	Circadian Clock Project, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa 2-1-6, Setagaya-ku, Tokyo, 156-8506, Japan.
contact email	yoshitane-hk@igakuken.or.jp
lab head
Hikari Yoshitane
contact affiliation	Tokyo Metropoitan Instituite of Medical Sciences
contact email	yoshitane-hk@igakuken.or.jp
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD044343
     1. Label: PRIDE project
     2. Name: Proteome analysis in the TcMAC21 mouse model of Down syndrome