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PXD044343-1

PXD044343 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome analysis in the TcMAC21 mouse model of Down syndrome
DescriptionDown syndrome (DS) results from trisomy of human chromosome 21 (HSA21), and DS research has been greatly advanced by the use of mouse models. We previously generated a humanized mouse model of DS, TcMAC21, which carries the long arm of HSA21. These mice exhibit learning and memory deficits, and may reproduce neurodevelopmental alterations observed in humans with DS. Here we performed histologic studies of the TcMAC21 forebrain from embryonic to adult stages. The TcMAC21 neocortex showed reduced proliferation of neural progenitors and delayed neurogenesis. These abnormalities were associated with a smaller number of projection neurons and interneurons. Further, (phospho-)proteomic analysis of adult TcMAC21 cortex revealed alterations in the phosphorylation levels of a series of synaptic proteins. The TcMAC21 mouse model shows similar brain development abnormalities as DS, and will be a valuable mode to investigate prenatal and postnatal causes of intellectual disability in humans with DS.
HostingRepositoryPRIDE
AnnounceDate2023-10-23
AnnouncementXMLSubmission_2023-10-22_23:35:36.824.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHikariYoshitane
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-03 23:52:16ID requested
12023-10-22 23:35:37announced
22024-10-22 06:06:55announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: LC-MSMS, Down syndrome, phospho-proteome,TcMAC21
Contact List
HikariYoshitane
contact affiliationCircadian Clock Project, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa 2-1-6, Setagaya-ku, Tokyo, 156-8506, Japan.
contact emailyoshitane-hk@igakuken.or.jp
lab head
HikariYoshitane
contact affiliationTokyo Metropoitan Instituite of Medical Sciences
contact emailyoshitane-hk@igakuken.or.jp
dataset submitter
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Dataset FTP location
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