PXD043608 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Therapeutic potential of pomegranate juice-derived nanovesicles in nude mouse benign prostatic hyperplasia (BPH) xenograft model |
Description | Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms affect a large percentage of the male population and places a substantial burden on the world health system. Current therapies include 5-alpha reductase inhibitors and alpha-blockers that are only partially effective and pose a huge economic burden, emphasizing the urgent need for effective, economical therapies. We isolated nanovesicles from pomegranate juice (Punica Granatum) (referred to as ‘POM-NVs’) and report to our knowledge for the first time, that these vesicles possess therapeutic potential against BPH. Following extensive characterization of POM-NVs, we tested their therapeutic potential in vitro using BPH1 cell line and identified a potential anti-proliferative and pro-apoptotic effect. We further tested these vesicles using a clinically relevant xenograft mouse BPH model derived from human BPH tissues. Remarkably, POM-NVs could reverse the BPH phenotype conferred by TGF-β mediated signaling and induced epithelial-to-mesenchymal (EMT) reversal, leading to the restoration of prostate epithelial states in vivo and in vitro. Furthermore, these vesicles attenuated bone morphogenic protein 5 (BMP5) signaling, a cardinal alteration that is instrumental in driving BPH. Considering the large incidences of BPH and its associated economic burdens, our study has important implications and can potentially improve the clinical management of BPH. |
HostingRepository | PRIDE |
AnnounceDate | 2023-07-18 |
AnnouncementXML | Submission_2023-07-18_10:16:00.761.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sharanjot Saini |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: 'Punica granatum' phytoplasma; NCBI TaxID: 1532734; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-07 09:58:19 | ID requested | |
⏵ 1 | 2023-07-18 10:16:01 | announced | |
2 | 2024-10-22 05:54:15 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Plant-derived nanovesicles, pomegranate juice derived nanovesicles, LC-MS/MS |
Contact List
SharanjotSaini |
contact affiliation | Augusta University |
contact email | ssaini@augusta.edu |
lab head | |
Sharanjot Saini |
contact affiliation | Augusta University |
contact email | ssaini@augusta.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043608
- Label: PRIDE project
- Name: Therapeutic potential of pomegranate juice-derived nanovesicles in nude mouse benign prostatic hyperplasia (BPH) xenograft model