PXD043573-1

PXD043573 is an original dataset announced via ProteomeXchange.

Title	Artemisinin mediates neuroprotection against Parkinson’s disease by targeting Adcy5-Gch1-BH4 axis
Description	Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with high disability. Hyposecretion of dopamine (DA) is the final pathological outcome of PD occurrence. Unfortunately, safe and efficient therapeutic drugs are deficient. Tyrosine hydroxylase (TH), the rate-limiting enzyme for DA synthesis, could hydroxylate tyrosine and generate levodopa with tetrahydrobiopterin (BH4) as an indispensable coenzyme. Moreover, BH4 was confirmed to confer neuroprotection against PD. Thus, regulation of BH4 synthesis is verified to become a promising therapeutic strategy for PD. Here, this present study exhibited that artemisinin (ART) effectively produced neuroprotection against PD. Then, the combined analysis of midbrain proteomics with non-targeted metabolomics indicated that ART might target adenylate cyclase 5 (Adcy5) to increase GTP cyclohydrolase 1 (Gch1, BH4 synthetase) expression to further promote BH4 synthesis. To test this hypothesis, molecular docking showed that ART could bind to Adcy5 d
HostingRepository	iProX
AnnounceDate	2023-07-06
AnnouncementXML	Submission_2023-07-05_22:52:23.490.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinxing Yang
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	TMT quantitation analysis

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-05 22:51:52	ID requested
⏵ 1	2023-07-05 22:52:23	announced

Dataset with its publication pending

submitter keyword: Parkinson’s diseas, Artemisinin, Adcy5, Gch1, Tetrahydrobiopterin

Feng Zhang
contact affiliation	Zunyi Medical University
contact email	zhangfengzmc@163.com
lab head
Xinxing Yang
contact affiliation	Zunyi Medical University
contact email	859243802@qq.com
dataset submitter

iProX dataset URI