PXD042366 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Secretome analysis of breast cancer cells treated with Ipomoea turpethum extract-loaded polymeric nanoparticles. |
Description | Nanoparticle-based formulations bypass biological barriers, allowing for longer blood circulation times, simultaneous tumor targeting, and increased drug accumulation in tumors. They have a higher therapeutic efficiency than traditional treatment due to better specificity for effective drug targeting, no solubility, and stability issues. In our previous study, we showed that Ipomoea turpethum extract-loaded polymeric nanoparticles induce cytotoxicity in breast cancer cell lines (MCF-7 and MDA MB-231) by regulating pathways involved in apoptosis and cell proliferation 9. Many researchers demonstrated the use of tumor microenvironments for prognostic, diagnostics, and therapeutic purposes. In the present study, we have analyzed the effect of NVA-IT treatment on the tumor microenvironment via secretory proteins present in the medium of the tumor cells. We have used Nano LCMS/MS to identify the differentially expressed proteins present in the culture medium of the NVA-IT treated tumor cells compared to untreated tumor cells. The differentially expressed proteins were further analyzed using bioinformatics tools. |
HostingRepository | PRIDE |
AnnounceDate | 2023-10-10 |
AnnouncementXML | Submission_2023-10-10_00:31:13.520.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | SAIMAWAJID |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-05-20 03:33:26 | ID requested | |
⏵ 1 | 2023-10-10 00:31:13 | announced | |
2 | 2023-11-14 08:26:26 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Bioinformatics., Nano LCMS/MS, Ipomoea turpethum, Nanoparticles, Secretome analysis,Breast Cancer |
Contact List
Dr. SaimaWajid |
contact affiliation | Department of Biotechnology, School of Chemical & Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India |
contact email | swajid@jamiahamdard.ac.in |
lab head | |
SAIMAWAJID |
contact affiliation | Department of Biotechnology, School of Chemical & Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062. |
contact email | swajid@jamiahamdard.ac.in |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD042366
- Label: PRIDE project
- Name: Secretome analysis of breast cancer cells treated with Ipomoea turpethum extract-loaded polymeric nanoparticles.