PXD041284-2

PXD041284 is an original dataset announced via ProteomeXchange.

Title	O-GlcNAcylation elevates topoisomerase IIα catalytic activity: a role in the chemotherapy resistance of breast cancer
Description	DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs. However, it is currently unknown whether TOP2A is O-GlcNAc-modified, and the mechanism by which interplay between TOP2A and O-GlcNAcylation affects breast cancer chemotherapeutic drug resistance remains unclear.
HostingRepository	iProX
AnnounceDate	2023-03-31
AnnouncementXML	Submission_2024-06-06_00:53:24.719.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yubo Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	O-(N-acetylglucosamine-1-phosphoryl)-L-serine
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-02 19:13:31	ID requested
1	2023-04-02 19:14:18	announced
⏵ 2	2024-06-06 00:53:25	announced	2024-06-06: Update information.

Liu Y, Yu K, Zhang K, Niu M, Chen Q, Liu Y, Wang L, Zhang N, Li W, Zhong X, Li G, Wu S, Zhang J, Liu Y, catalytic activity in breast cancer chemoresistance. EMBO Rep, 24(7):e56458(2023) [pubmed]

submitter keyword: TOP2A, O-GlcNAcylation, site identification

Yubo Liu
contact affiliation	Dalian University of Technology
contact email	liuyubo623@163.com
lab head
Yubo Liu
contact affiliation	Dalian University of technology
contact email	liuyubo623@163.com
dataset submitter

iProX dataset URI