PXD041284-1
PXD041284 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | O-GlcNAcylation elevates topoisomerase IIα catalytic activity: a role in the chemotherapy resistance of breast cancer |
| Description | DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs. However, it is currently unknown whether TOP2A is O-GlcNAc-modified, and the mechanism by which interplay between TOP2A and O-GlcNAcylation affects breast cancer chemotherapeutic drug resistance remains unclear. |
| HostingRepository | iProX |
| AnnounceDate | 2023-03-31 |
| AnnouncementXML | Submission_2023-04-02_19:14:18.134.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yubo Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | O-(N-acetylglucosamine-1-phosphoryl)-L-serine |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-04-02 19:13:31 | ID requested | |
| ⏵ 1 | 2023-04-02 19:14:18 | announced | |
| 2 | 2024-06-06 00:53:25 | announced | 2024-06-06: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: TOP2A, O-GlcNAcylation, site identification |
Contact List
| Yubo Liu | |
|---|---|
| contact affiliation | Dalian University of Technology |
| contact email | liuyubo623@163.com |
| lab head | |
| Yubo Liu | |
| contact affiliation | Dalian University of technology |
| contact email | liuyubo623@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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