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PXD040598-1

PXD040598 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtein abundances following 24h of SPARK depletion in Toxoplasma gondii
DescriptionToxoplasma gondii is a ubiquitous eukaryotic pathogen. Apicomplexan parasites-the family to which T. gondii belongs-possess a divergent ortholog of mammalian PDK1. We have previously shown that this store potentiating/activating regulatory kinase (SPARK) is essential for T. gondii motility, invasion, and egress. Here, we conditionally depleted SPARK in live parasites for 24 hours to determine the impact of SPARK function on the parasite proteome.
HostingRepositoryPRIDE
AnnounceDate2024-10-08
AnnouncementXMLSubmission_2024-10-08_11:38:37.402.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD040598
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAlice Herneisen
SpeciesList scientific name: Toxoplasma gondii GT1; NCBI TaxID: 507601;
ModificationListmethylthiolated residue; acetylated residue; monohydroxylated residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-05 08:35:17ID requested
12024-10-08 11:38:37announced
22024-10-22 06:49:30announced2024-10-22: Updated project metadata.
Publication List
10.6019/PXD040598;
10.7554/ELIFE.93877.1;
Keyword List
submitter keyword: Toxoplasma, PDK1, parasite
Contact List
Sebastian Lourido
contact affiliationWhitehead Institute for Biomedical Research and Massachusetts Institute of Technology
contact emaillourido@wi.mit.edu
lab head
Alice Herneisen
contact affiliationWhitehead Institute for Biomedical Research, Cambridge, MA, USA 02142 Department of Biology, Massachusetts Insitute of Technology
contact emailalice@wi.mit.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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