PXD038222
PXD038222 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Phosphoproteome analysis of MB mice cerebella tissue |
| Description | Aberrant activation of sonic hedgehog (SHH) signaling is critical for oncogenesis of SHH-dependent medulloblastoma (MBSHH) and basal cell carcinoma (BCC). Here, we quanti-tatively characterized phosphoproteomic changes in an GFAP-Cre;SMO-M2 and Smo-M2 control transgenic mouse using high-resolution mass spectrometry, profiled 6692 phospphorylation sites on 2553 proteins. Our results, revealed that 142 differentially expressed phospho-proteins were significantly upregulated, such as heterogeneous nuclear ribonucleoprotein C (Hnrnpc), protein kinase C (PKC), PKC, and autophagy-related protein 9A (Atg9a), and 86 differentially expressed phospho-proteins were significantly down-regulated, such as DNA polymerase 2 (Pola2), nucleoporin 210 (Nup210), and p38 and MAPKs. Our phosphoproteome data facilitated the construction of detailed molecular landscape in MB and should serve as a resource for the brain tumors community. |
| HostingRepository | iProX |
| AnnounceDate | 2022-11-19 |
| AnnouncementXML | Submission_2024-02-28_18:55:30.716.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jirong Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-20 22:43:00 | ID requested | |
| 1 | 2024-01-16 17:42:25 | announced | |
| ⏵ 2 | 2024-02-28 18:55:31 | announced | 2024-02-29: Update information. |
Publication List
| Zeng LH, Tang C, Yao M, He Q, Qv M, Ren Q, Xu Y, Shen T, Gu W, Xu C, Zou C, Ji X, Wu X, Wang J, Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastoma. Nat Commun, 15(1):987(2024) [pubmed] |
Keyword List
| submitter keyword: Medulloblastoma, Cerebella, PTMs, phosphroteome |
Contact List
| Ximei Wu | |
|---|---|
| contact affiliation | Zhejiang University |
| contact email | xiwu@zju.edu.cn |
| lab head | |
| Jirong Wang | |
| contact affiliation | Zhejiang University |
| contact email | wangjr@zju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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