PXD038222-1

PXD038222 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteome analysis of MB mice cerebella tissue
Description	Aberrant activation of sonic hedgehog (SHH) signaling is critical for oncogenesis of SHH-dependent medulloblastoma (MBSHH) and basal cell carcinoma (BCC). Here, we quanti-tatively characterized phosphoproteomic changes in an GFAP-Cre;SMO-M2 and Smo-M2 control transgenic mouse using high-resolution mass spectrometry, profiled 6692 phospphorylation sites on 2553 proteins. Our results, revealed that 142 differentially expressed phospho-proteins were significantly upregulated, such as heterogeneous nuclear ribonucleoprotein C (Hnrnpc), protein kinase C  (PKC), PKC, and autophagy-related protein 9A (Atg9a), and 86 differentially expressed phospho-proteins were significantly down-regulated, such as DNA polymerase 2 (Pola2), nucleoporin 210 (Nup210), and p38 and MAPKs. Our phosphoproteome data facilitated the construction of detailed molecular landscape in MB and should serve as a resource for the brain tumors community.
HostingRepository	iProX
AnnounceDate	2022-11-19
AnnouncementXML	Submission_2024-01-16_17:42:24.950.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jirong Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-20 22:43:00	ID requested
⏵ 1	2024-01-16 17:42:25	announced
2	2024-02-28 18:55:31	announced	2024-02-29: Update information.

Dataset with its publication pending

submitter keyword: Medulloblastoma, Cerebella, PTMs, phosphroteome

Ximei Wu
contact affiliation	Zhejiang University
contact email	xiwu@zju.edu.cn
lab head
Jirong Wang
contact affiliation	Zhejiang University
contact email	wangjr@zju.edu.cn
dataset submitter

iProX dataset URI