PXD037918-2

PXD037918 is an original dataset announced via ProteomeXchange.

Title	Citrullinated glucose-regulated protein 78 is a candidate target for cancer immunotherapy
Description	In this study we investigate the potential of targeting citrullinated GRP78 for cancer therapy. We select five peptides and show the identification CD4 T cell responses to one citrullinated GRP78 epitope that is restricted through HLA DP*0401 and HLA-DR*0101 alleles. This peptide is detected by mass spectrometry in B16 melanoma grown in vivo and citrulline specific CD4 responses to this epitope mediate efficient therapy of established B16 melanoma tumours in HHDII/DP4 transgenic mouse model. We demonstrate the existence of a repertoire of responses to the citrullinated GRP78 peptide in healthy individuals.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:58:30.754.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Bremang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	L-citrulline
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-03 04:48:25	ID requested
1	2022-11-29 06:07:08	announced
⏵ 2	2023-11-14 08:58:31	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Citrullination, peptidomics, immunotherapy, GRP78

Victoria Brentville
contact affiliation	Scancell Unit 202 Bellhouse Building Sanders Road Oxford Science Park Oxford OX4 4GD UK
contact email	VictoriaBrentville@scancell.co.uk
lab head
Michael Bremang
contact affiliation	Proteome Sciences
contact email	michael.bremang@proteomics.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD037918

PRIDE project URI

• PRIDE
  1. PXD037918
     1. Label: PRIDE project
     2. Name: Citrullinated glucose-regulated protein 78 is a candidate target for cancer immunotherapy