PXD037918 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Citrullinated glucose-regulated protein 78 is a candidate target for cancer immunotherapy |
| Description | In this study we investigate the potential of targeting citrullinated GRP78 for cancer therapy. We select five peptides and show the identification CD4 T cell responses to one citrullinated GRP78 epitope that is restricted through HLA DP*0401 and HLA-DR*0101 alleles. This peptide is detected by mass spectrometry in B16 melanoma grown in vivo and citrulline specific CD4 responses to this epitope mediate efficient therapy of established B16 melanoma tumours in HHDII/DP4 transgenic mouse model. We demonstrate the existence of a repertoire of responses to the citrullinated GRP78 peptide in healthy individuals. |
| HostingRepository | PRIDE |
| AnnounceDate | 2022-11-29 |
| AnnouncementXML | Submission_2022-11-29_06:07:08.307.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | MichaelBremang |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | L-citrulline |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-11-03 04:48:25 | ID requested | |
| ⏵ 1 | 2022-11-29 06:07:08 | announced | |
| 2 | 2023-11-14 08:58:31 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: Citrullination, peptidomics, immunotherapy, GRP78 |
Contact List
| VictoriaBrentville |
|---|
| contact affiliation | Scancell Unit 202 Bellhouse Building Sanders Road Oxford Science Park Oxford OX4 4GD UK |
| contact email | VictoriaBrentville@scancell.co.uk |
| lab head | |
| MichaelBremang |
|---|
| contact affiliation | Proteome Sciences |
| contact email | michael.bremang@proteomics.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD037918 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037918
- Label: PRIDE project
- Name: Citrullinated glucose-regulated protein 78 is a candidate target for cancer immunotherapy
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