PXD037134 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comprehensive glycoprofiling of oral tumours associates N-glycosylation with lymph node metastasis and patient survival |
Description | While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), its heterogeneous glycoproteome and dynamics with disease progression remain unmapped. Employing an integrated multi-omics approach comprising unbiased and quantitative glycomics and glycoproteomics on resected OSCC tissues, we firstly profiled the N-glycome that overall displayed uniform expression in OSCC patients with (N+, n = 19) and without (N0, n = 12) lymph node metastasis, suggesting relatively stable N-glycosylation during metastasis. Notably, glycoproteomics and advanced correlation analysis uncovered altered site-specific N-glycosylation and associations with clinicopathological features. Importantly, targeted analyses of the multi-omics data unveiled two N-glycans and three N-glycopeptides that were closely associated with patient survival. This study provides novel insight into the complex OSCC tissue N-glycoproteome forming an important resource to further explore the underpinning disease mechanisms and uncover new prognostic glyco-markers for OSCC. |
HostingRepository | PRIDE |
AnnounceDate | 2023-06-08 |
AnnouncementXML | Submission_2023-06-08_12:28:12.377.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | AdrianaFranco Paes Leme |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-02 03:58:00 | ID requested | |
⏵ 1 | 2023-06-08 12:28:12 | announced | |
2 | 2023-11-14 09:01:11 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Glycomics, Lymph node metastasis, Glycoproteomics,Glycosylation, Glycoproteome, Oral Cancer |
Contact List
Adriana Franco PaesLeme |
contact affiliation | Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa emEnergia e Materiais (CNPEM) (lab head) |
contact email | adriana.paesleme@lnbio.cnpem.br |
lab head | |
AdrianaFranco Paes Leme |
contact affiliation | CNPEM |
contact email | adriana.paesleme@lnbio.cnpem.br |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037134
- Label: PRIDE project
- Name: Comprehensive glycoprofiling of oral tumours associates N-glycosylation with lymph node metastasis and patient survival