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PXD035474-1

PXD035474 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMulti-organ proteomic and phosphoproteomic landscape of K18-hACE2 mice infected with SARS-CoV-2
DescriptionEight 10-week-old female K18-hACE2 mice were equally divided into control (n = 4) and virus-infected group (n = 4). Mice in the virus-infected group were challenged with 10^5 median tissue culture infective dose (TCID50) of SARS-CoV-2 virus by intranasal inoculation and mice in the control group were treated with equal volumes of PBS. On 5 days post infection (dpi), all the mice were euthanized and their cortex, hippocampus, thalamus, lung, and kidney were harvested for viral load detection, morphological analysis, and LC-MS-based label-free proteome and phosphoproteome analysis.
HostingRepositoryiProX
AnnounceDate2022-07-21
AnnouncementXMLSubmission_2023-08-31_18:32:45.512.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiangfeng Liu
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListphosphorylated residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-21 00:51:08ID requested
12023-08-31 18:32:47announced
Publication List
Liu JF, Peng WJ, Wu Y, Yang YH, Wu SF, Liu DP, Liu JN, Yang JT, Proteomic and phosphoproteomic characteristics of the cortex, hippocampus, thalamus, lung, and kidney in COVID-19-infected female K18-hACE2 mice. EBioMedicine, 90():104518(2023) [pubmed]
Keyword List
submitter keyword: COVID-19, label free, proteomics, phosphoproteomics, K18-hACE2 mice, multi-organ
Contact List
Juntao Yang
contact affiliationPeking Union Medical College
contact emailyangjt@pumc.edu.cn
lab head
Jiangfeng Liu
contact affiliationPeking Union Medical College
contact emailljf@pumc.edu.cn
dataset submitter
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iProX dataset URI