PXD035230 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Repurposing of a known antipsychotic drug to target arthritogenic synovial fibroblasts |
Description | We applied quantitative mass spectrometry (MS)-based proteomics to investigate the phosphoproteome of hTNF-stimulated and Amisulpride-treated synovial fibroblasts (SFs), as part of a study aiming to find new potent orally-administered therapeutics to reverse the pathogenic expression signature of arthritogenic SFs. Phosphoproteomics analysis were done by DIA-based phosphoproteomic profiling of synovial fibroblasts. Samples consisted of hTNF-induced WT SFs. Three different time points (5’, 15’, 30’) of hTNF induction were used and compared to cells pretreated with Amisulpride for 1h before being stimulated at similar time points with hTNF (5’, 15’, 30’). |
HostingRepository | PRIDE |
AnnounceDate | 2023-04-11 |
AnnouncementXML | Submission_2023-04-11_07:13:52.042.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Anna-KathrinePedersen |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-11 08:07:04 | ID requested | |
⏵ 1 | 2023-04-11 07:13:52 | announced | |
2 | 2023-11-14 08:57:35 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: LC-MSMS, small molecule repurposing, tumor necrosis factor alpha,Rheumatoid arthritis, synovial fibroblasts |
Contact List
Jesper VelgaardOlsen |
contact affiliation | Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark |
contact email | jesper.olsen@cpr.ku.dk |
lab head | |
Anna-KathrinePedersen |
contact affiliation | NNF Center for Protein Research, University of Copenhagen |
contact email | anna-kathrine.pedersen@cpr.ku.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035230
- Label: PRIDE project
- Name: Repurposing of a known antipsychotic drug to target arthritogenic synovial fibroblasts