PXD035194 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Monoclonal antibody affinity-enrichment pull-down proteomics for Fasciola hepatica gut-associated proteins |
| Description | The zoonotic liver fluke Fasciola hepatica is responsible for economic losses to the agriculture industry worldwide. Triclabendazole has been the drug of choice. However, anthelmintic resistance is becoming prevalent with cases of resistance detected globally. This emphasizes the need for alternative control methods. A significant focus is on the development of protein vaccines. In this process however, glycoproteins (GPs) have been mostly ignored. GPs are present throughout the organ systems of F. hepatica and such gut-associated GPs could serve as ‘hidden’ antigens. Hidden antigens are not initially exposed to the host’s immune system during the course of natural infections, but have proven to be effective vaccine candidates, notably for antigens that are present in the intestine of blood-feeding and tissue-dwelling parasites. This work describes the purification of gut-associated parasite GPs based on protective antibodies against adult flukes in vitro, which demonstrate a binding on fluke gut structures. Finally, we provide a list of promising novel F. hepatica gut-associated vaccine candidates. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-29 |
| AnnouncementXML | Submission_2026-06-28_16:47:55.468.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD035194 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Ramon Eichenberger |
| SpeciesList | scientific name: Fasciola hepatica (Liver fluke); NCBI TaxID: NEWT:6192; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-07-09 08:51:10 | ID requested | |
| ⏵ 1 | 2026-06-28 16:47:56 | announced | |
Publication List
| Rechsteiner SG, Hasler S, Gehrig P, Deplazes P, Eichenberger RM, gut-associated glycoproteins as potential vaccine candidates by lectin-affinity chromatography, flukicidal monoclonal antibodies, and affinity-enrichment mass spectrometry. Front Parasitol, 5():1746419(2026) [pubmed] |
| 10.3389/fpara.2026.1746419; |
| 10.6019/PXD035194; |
Keyword List
| submitter keyword: Fasciola hepatica, monoclonal antibody, gut antigen, proteomics, mass spectrometry, pull-down, liver fluke |
Contact List
| Ramon Marc Eichenberger |
|---|
| contact affiliation | Institute of Parasitology, University of Zurich, Zurich, Switzerland |
| contact email | ramon.eichenberger@uzh.ch |
| lab head | |
| Ramon Eichenberger |
|---|
| contact affiliation | Institute of Parasitology, University of Zurich, Zurich, Switzerland |
| contact email | ramon.eichenberger@uzh.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD035194 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035194
- Label: PRIDE project
- Name: Monoclonal antibody affinity-enrichment pull-down proteomics for Fasciola hepatica gut-associated proteins
