PXD035061-2
PXD035061 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and Represents a Therapeutic Vulnerability in Hepatocellular Carcinoma |
| Description | Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, we found that R236 methylation of PHGDH promotes its activity and stimulates serine synthesis in hepatocellular carcinoma. |
| HostingRepository | iProX |
| AnnounceDate | 2022-07-28 |
| AnnouncementXML | Submission_2023-03-01_19:00:53.252.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kui Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | monomethylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-07-03 23:54:44 | ID requested | |
| 1 | 2022-07-03 23:54:50 | announced | |
| ⏵ 2 | 2023-03-01 19:00:54 | announced | 2023-03-02: Update publication information. |
Publication List
| Wang K, Luo L, Fu S, Wang M, Wang Z, Dong L, Wu X, Dai L, Peng Y, Shen G, Chen HN, Nice EC, Wei X, Huang C, PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. Nat Commun, 14(1):1011(2023) [pubmed] |
Keyword List
| submitter keyword: PHGDH, arginine methylation |
Contact List
| Canhua Huang | |
|---|---|
| contact affiliation | Sichuan University |
| contact email | hcanhua68@163.com |
| lab head | |
| Kui Wang | |
| contact affiliation | Sichuan University |
| contact email | wangkui416@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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