PXD033741-2

PXD033741 is an original dataset announced via ProteomeXchange.

Title	Proteomic Characterization of Epithelial Ovarian Cancer Delineates Molecular Signatures and Therapeutic Targets in Distinct Histological Subtypes
Description	Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear. Here, we undertake comprehensive proteomic profiling of 80 CCC, 79 EC, 80 SC, and 30 control samples. Our analysis reveals the prognostic or diagnostic value of dysregulated proteins and phosphorylation sites in important pathways. Moreover, protein co-expression network not only provides comprehensive view of biological features of each histological subtype, but also indicate potential prognostic biomarkers and progression landmarks. Notably, EOC have strong inter-tumor heterogeneity, with significantly different clinical characteristics, proteomic patterns and signaling pathway disorders in CCC, EC, and SC. Finally, we infer MPP7 protein as potential therapeutic target for SC, whose biological functions are confirmed in SC cells. Our proteomic cohort provides valuable resources for understanding molecular mechanisms and developing treatment strategies of distinct histological subtypes.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:13:37.281.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qi-Jun Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-06 04:57:26	ID requested
1	2023-10-30 11:44:12	announced
⏵ 2	2024-10-22 06:13:38	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: epithelial ovarian cancer；proteomics；histological subtype；tumor biomarkers；drug target

Qi-Jun Wu
contact affiliation	Shengjing hospital of China Medical University
contact email	wuqj@sj-hospital.org
lab head
Qi-Jun Wu
contact affiliation	Shengjing hospital of China Medical University
contact email	wuqj@sj-hospital.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD033741
     1. Label: PRIDE project
     2. Name: Proteomic Characterization of Epithelial Ovarian Cancer Delineates Molecular Signatures and Therapeutic Targets in Distinct Histological Subtypes