PXD033741 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Characterization of Epithelial Ovarian Cancer Delineates Molecular Signatures and Therapeutic Targets in Distinct Histological Subtypes |
Description | Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear. Here, we undertake comprehensive proteomic profiling of 80 CCC, 79 EC, 80 SC, and 30 control samples. Our analysis reveals the prognostic or diagnostic value of dysregulated proteins and phosphorylation sites in important pathways. Moreover, protein co-expression network not only provides comprehensive view of biological features of each histological subtype, but also indicate potential prognostic biomarkers and progression landmarks. Notably, EOC have strong inter-tumor heterogeneity, with significantly different clinical characteristics, proteomic patterns and signaling pathway disorders in CCC, EC, and SC. Finally, we infer MPP7 protein as potential therapeutic target for SC, whose biological functions are confirmed in SC cells. Our proteomic cohort provides valuable resources for understanding molecular mechanisms and developing treatment strategies of distinct histological subtypes. |
HostingRepository | PRIDE |
AnnounceDate | 2023-10-30 |
AnnouncementXML | Submission_2023-10-30_11:44:12.049.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Qi-JunWu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-06 04:57:26 | ID requested | |
⏵ 1 | 2023-10-30 11:44:12 | announced | |
2 | 2024-10-22 06:13:38 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: epithelial ovarian cancer;proteomics;histological subtype;tumor biomarkers;drug target |
Contact List
Qi-JunWu |
contact affiliation | Shengjing hospital of China Medical University |
contact email | wuqj@sj-hospital.org |
lab head | |
Qi-JunWu |
contact affiliation | Shengjing hospital of China Medical University |
contact email | wuqj@sj-hospital.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033741
- Label: PRIDE project
- Name: Proteomic Characterization of Epithelial Ovarian Cancer Delineates Molecular Signatures and Therapeutic Targets in Distinct Histological Subtypes