PXD033034-2
PXD033034 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Large-scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis |
Description | Neurosyphilis (NS) is a central nervous system infection caused by Treponema pallidum. NS can occur at any stage of syphilis and manifests as a broad spectrum of clinical symptoms. Often referred to as “the great imitator”, NS can be easily overlooked or misdiagnosed due to the absence of standard diagnostic tests, potentially leading to severe and irreversible organ dysfunction. In this study, proteomic and machine learning model techniques were used to characterize 223 cerebrospinal fluid (CSF) samples to identify diagnostic markers of NS and provide insights into the underlying mechanisms of the associated inflammatory responses. Three biomarkers (SEMA7A, SERPINA3, and ITIH4) were validated as contributors to NS diagnosis through multicenter verification of an additional 115 CSF samples. We anticipate that the identified biomarkers will become effective tools for assisting in diagnosis of NS. Our insights into NS pathogenesis in brain tissue may inform therapeutic strategies and drug discoveries for NS patients. |
HostingRepository | iProX |
AnnounceDate | 2024-02-16 |
AnnouncementXML | Submission_2024-02-17_22:46:29.397.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jie Ma |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-04-06 20:30:12 | ID requested | |
1 | 2024-02-17 22:37:35 | announced | |
⏵ 2 | 2024-02-17 22:46:29 | announced | 2024-02-18: Update information. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Cerebrospinal fluid, diagnostic biomarker, machine learning model, neurosyphilis, proteomics |
Contact List
Ling Leng | |
---|---|
contact affiliation | Peking Union Medical College Hospital |
contact email | lengling@pumch.cn |
lab head | |
Jie Ma | |
contact affiliation | National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics |
contact email | majie@ncpsb.org.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |