PXD029291 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products |
| Description | The COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest in the COVID mRNA vaccines, we sought to investigate how N1-methylpseudouridine (and the related modification pseudouridine) is read by ribosomes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-11-14 |
| AnnouncementXML | Submission_2023-11-14_08:55:07.280.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD029291 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Kyusik Kim |
| SpeciesList | scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos; Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2021-10-22 06:57:13 | ID requested | |
| 1 | 2022-08-18 12:41:58 | announced | |
| ⏵ 2 | 2023-11-14 08:55:08 | announced | 2023-11-14: Updated project metadata. |
Publication List
| Dataset with its publication pending |
Keyword List
| ProteomeXchange project tag: Sars-cov-2, Covid-19 |
| submitter keyword: SARS-CoV-2, N1-methylpseudouridine, ribosome, decoding, fidelity, COVID-19, mRNA vaccine, translation |
Contact List
| Hani Zaher |
|---|
| contact affiliation | Department of Biology, Washington University in St. Louis |
| contact email | hzaher@wustl.edu |
| lab head | |
| Kyusik Kim |
|---|
| contact affiliation | Washington University in St. Louis |
| contact email | kyusikkim@wustl.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD029291 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029291
- Label: PRIDE project
- Name: N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
to receive all new ProteomeXchange dataset release announcements!
