PXD029291-1

PXD029291 is an original dataset announced via ProteomeXchange.

Title	N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
Description	The COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest in the COVID mRNA vaccines, we sought to investigate how N1-methylpseudouridine (and the related modification pseudouridine) is read by ribosomes.
HostingRepository	PRIDE
AnnounceDate	2022-08-18
AnnouncementXML	Submission_2022-08-18_12:41:58.011.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD029291
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kyusik Kim
SpeciesList	scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-22 06:57:13	ID requested
⏵ 1	2022-08-18 12:41:58	announced
2	2023-11-14 08:55:08	announced	2023-11-14: Updated project metadata.

10.1016/J.CELREP.2022.111300;

submitter keyword: SARS-CoV-2, COVID-19, N1-methylpseudouridine, mRNA vaccine, ribosome, fidelity, translation, decoding

Hani Zaher
contact affiliation	Department of Biology, Washington University in St. Louis
contact email	hzaher@wustl.edu
lab head
Kyusik Kim
contact affiliation	Washington University in St. Louis
contact email	kyusikkim@wustl.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD029291
     1. Label: PRIDE project
     2. Name: N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products