PXD028689-2

PXD028689 is an original dataset announced via ProteomeXchange.

Title	THEMIS is a novel substrate and allosteric activator of SHP1, playing dual roles during T cell development
Description	By combining strategies of substrate trapping for PTPs and pupylation-based interaction tagging (PUP-IT) for protein-protein interaction, we develop a systematic proximity labeling methodology PEPSI in identifying novel substrate for PTPs. We apply this approach to SHP1 and surprisingly, identified THEMIS as an uncharacterized substrate for the phosphatase.
HostingRepository	iProX
AnnounceDate	2023-08-31
AnnouncementXML	Submission_2024-05-22_19:58:18.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiali Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-21 19:39:38	ID requested
1	2023-08-31 19:25:40	announced
⏵ 2	2024-05-22 19:58:19	announced	2024-05-23: Update information.

Zhang J, Jiang Z, Zhang X, Yang Z, Wang J, Chen J, Chen L, Song M, Zhang Y, Huang M, Chen S, Xiong X, Wang Y, Hao P, Horng T, Zhuang M, Zhang L, Zuo E, Bai F, Zheng J, Wang H, Fan G, THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development. Nat Struct Mol Biol, 31(1):54-67(2024) [pubmed]

submitter keyword: PEPSI, SHP1, THEMIS

Gaofeng Fan
contact affiliation	ShanghaiTech University
contact email	fangf@shanghaitech.edu.cn
lab head
Jiali Zhang
contact affiliation	ShanghaiTech University
contact email	zhangjl@shanghaitech.edu.cn
dataset submitter

iProX dataset URI