PXD028689-1
PXD028689 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | THEMIS is a novel substrate and allosteric activator of SHP1, playing dual roles during T cell development |
| Description | By combining strategies of substrate trapping for PTPs and pupylation-based interaction tagging (PUP-IT) for protein-protein interaction, we develop a systematic proximity labeling methodology PEPSI in identifying novel substrate for PTPs. We apply this approach to SHP1 and surprisingly, identified THEMIS as an uncharacterized substrate for the phosphatase. |
| HostingRepository | iProX |
| AnnounceDate | 2023-08-31 |
| AnnouncementXML | Submission_2023-08-31_19:25:39.690.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiali Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF; Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-09-21 19:39:38 | ID requested | |
| ⏵ 1 | 2023-08-31 19:25:40 | announced | |
| 2 | 2024-05-22 19:58:19 | announced | 2024-05-23: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PEPSI, SHP1, THEMIS |
Contact List
| Gaofeng Fan | |
|---|---|
| contact affiliation | ShanghaiTech University |
| contact email | fangf@shanghaitech.edu.cn |
| lab head | |
| Jiali Zhang | |
| contact affiliation | ShanghaiTech University |
| contact email | zhangjl@shanghaitech.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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