PXD028689-1
PXD028689 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | THEMIS is a novel substrate and allosteric activator of SHP1, playing dual roles during T cell development |
Description | By combining strategies of substrate trapping for PTPs and pupylation-based interaction tagging (PUP-IT) for protein-protein interaction, we develop a systematic proximity labeling methodology PEPSI in identifying novel substrate for PTPs. We apply this approach to SHP1 and surprisingly, identified THEMIS as an uncharacterized substrate for the phosphatase. |
HostingRepository | iProX |
AnnounceDate | 2023-08-31 |
AnnouncementXML | Submission_2023-08-31_19:25:39.690.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jiali Zhang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-09-21 19:39:38 | ID requested | |
⏵ 1 | 2023-08-31 19:25:40 | announced | |
2 | 2024-05-22 19:58:19 | announced | 2024-05-23: Update information. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: PEPSI, SHP1, THEMIS |
Contact List
Gaofeng Fan | |
---|---|
contact affiliation | ShanghaiTech University |
contact email | fangf@shanghaitech.edu.cn |
lab head | |
Jiali Zhang | |
contact affiliation | ShanghaiTech University |
contact email | zhangjl@shanghaitech.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |