PXD028189-1
PXD028189 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | An evolutionarily conserved mechanism to control the length-dependent translation |
| Description | Translation is a tightly regulated by numerous factors, among which mRNA length is a key factor to regulate translation efficiency. Compared with long mRNAs, short mRNAs are preferentially translated, which is called length-dependent translation. However, the underlying mechanism is largely unknown. Here we demonstrate that tRNA modification is a determinant of length-dependent translation. We found that loss of the evolutionarily conserved mcm5s2U modification of tRNA dramatically compromised immunity in Arabidopsis. Further analysis revealed that protein expression decreases with protein length in the absence of mcm5s2U modification, which is conserved in other eukaryotes. In consistence, tRNA modification affects the correlation between translation efficiency and mRNA length. Altogether, our study uncovers the link between tRNA modification and length-dependent translation, highlighting the importance of translation elongation in this process. |
| HostingRepository | iProX |
| AnnounceDate | 2021-08-30 |
| AnnouncementXML | Submission_2021-09-01_04:54:12.349.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xueao Zheng |
| SpeciesList | scientific name: Arabidopsis thaliana; NCBI TaxID: 3702; |
| ModificationList | TMT6plex reporter fragment |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-09-01 04:53:57 | ID requested | |
| ⏵ 1 | 2021-09-01 04:54:12 | announced | |
| 2 | 2022-07-04 20:23:37 | announced | 2022-07-05: Update information. |
| 3 | 2024-02-29 18:17:10 | announced | 2022-07-05: Update information. 2024-03-01: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: tRNA modification, length-dependent translation, elongation, immunity |
Contact List
| Shunping Yan | |
|---|---|
| contact affiliation | Huazhong Agricultural University |
| contact email | spyan@mail.hzau.edu.cn |
| lab head | |
| Xueao Zheng | |
| contact affiliation | Huazhong Agricultural University |
| contact email | zhengxueao@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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