PXD027744-2

PXD027744 is an original dataset announced via ProteomeXchange.

Title	THP-1 cells treated with plasticizer DINCH and metabolite MINCH
Description	Since 2008, the consumption of the plasticizer bis (2-ethylhexyl) phthalate (DEHP) in the manufacture of plastic products has been restricted due to several adverse health effects. 1,2-cyclohexanedicarboxylic acid diisononyl ester (DINCH) is increasingly used as a harmless substituent for DEHP. However, the structural similarity to DEHP and first studies demonstrating adverse effects on reproduction and metabolism in rats, suggest that DINCH may act adverse on human health. Still, there is a lack of studies on the biological effects of DINCH, especially in the immune system, which is in constant communication with other tissues and thus crucial for maintaining a functional organism. Here we aimed to investigate the effects of DINCH and its naturally occurring biotransformation product monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH) on the innate immune response. Human THP-1 macrophages were exposed to DINCH and MINCH in a concentration range of 10 nM to 10 μM for 4 h, 16 h and 24 h in the presence of LPS.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:53:07.193.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD027744
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Alexandra Schaffert
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-05 09:59:55	ID requested
1	2022-01-10 02:52:55	announced
⏵ 2	2023-11-14 08:53:07	announced	2023-11-14: Updated project metadata.

10.6019/PXD027744;

submitter keyword: endocrine disruption, plasticizers, MINCH,DINCH

Kristin Schubert
contact affiliation	Helmholtz-Centre for Environmental Research – UFZ Leipzig, Germany
contact email	kristin.schubert@ufz.de
lab head
Alexandra Schaffert
contact affiliation	Helmholtz-Centre for Environmental Research
contact email	alexandra.schaffert@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/01/PXD027744

PRIDE project URI

• PRIDE
  1. PXD027744
     1. Label: PRIDE project
     2. Name: THP-1 cells treated with plasticizer DINCH and metabolite MINCH