PXD027744 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | THP-1 cells treated with plasticizer DINCH and metabolite MINCH |
Description | Since 2008, the consumption of the plasticizer bis (2-ethylhexyl) phthalate (DEHP) in the manufacture of plastic products has been restricted due to several adverse health effects. 1,2-cyclohexanedicarboxylic acid diisononyl ester (DINCH) is increasingly used as a harmless substituent for DEHP. However, the structural similarity to DEHP and first studies demonstrating adverse effects on reproduction and metabolism in rats, suggest that DINCH may act adverse on human health. Still, there is a lack of studies on the biological effects of DINCH, especially in the immune system, which is in constant communication with other tissues and thus crucial for maintaining a functional organism. Here we aimed to investigate the effects of DINCH and its naturally occurring biotransformation product monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH) on the innate immune response. Human THP-1 macrophages were exposed to DINCH and MINCH in a concentration range of 10 nM to 10 μM for 4 h, 16 h and 24 h in the presence of LPS. |
HostingRepository | PRIDE |
AnnounceDate | 2022-01-10 |
AnnouncementXML | Submission_2022-01-10_02:52:55.251.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD027744 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Alexandra Schaffert |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-05 09:59:55 | ID requested | |
⏵ 1 | 2022-01-10 02:52:55 | announced | |
2 | 2023-11-14 08:53:07 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: DINCH, MINCH, endocrine disruption, plasticizers |
Contact List
Kristin Schubert |
contact affiliation | Helmholtz-Centre for Environmental Research – UFZ Leipzig, Germany |
contact email | kristin.schubert@ufz.de |
lab head | |
Alexandra Schaffert |
contact affiliation | Helmholtz-Centre for Environmental Research |
contact email | alexandra.schaffert@ufz.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/01/PXD027744 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027744
- Label: PRIDE project
- Name: THP-1 cells treated with plasticizer DINCH and metabolite MINCH