⮝ Full datasets listing
PXD026780-1
PXD026780 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics analysis for RBM17 in acute myeloid leukemia |
| Description | Acute myeloid leukemia (AML) patients suffer from chemo-resistance, high relapse frequency, and low overall survival rate, outcomes driven by leukemic stem cells (LSCs). Understanding the molecular mechanisms that support these primitive leukemic cells is crucial for developing effective AML therapeutics. In the present study, we demonstrate that upregulation of the splicing factor RBM17 preferentially marks and sustains the primitive compartment of AML. We performed shotgun proteomics to characterize the proteome changes upon RBM17 knockdown in AMl cells. In addition, we used proteomics to analyze the proteome changes after knockdown of EIF4A2, a direct splicing substrate of RBM17 in AML cells. |
| HostingRepository | PRIDE |
| AnnounceDate | 2022-08-12 |
| AnnouncementXML | Submission_2022-08-12_05:53:33.417.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yu Lu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-06-18 03:49:47 | ID requested | |
| ⏵ 1 | 2022-08-12 05:53:34 | announced |
Publication List
Keyword List
| submitter keyword: RBM17, EIF4A2, AML, acute myeloid leukemia, splicing |
Contact List
| Yu Lu | |
|---|---|
| contact affiliation | Department of Biochemistry and Biomedical Sciences McMaster University |
| contact email | yu.lu@mcmaster.ca |
| lab head | |
| Yu Lu | |
| contact affiliation | McMaster University |
| contact email | yu.lu@mcmaster.ca |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD026780 |
| PRIDE project URI |
Repository Record List
[ + ]
