PXD026380 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Analysis of Estrogen Mediated Enhancement of MSC-Induced Angiogenesis in vivo |
Description | Therapeutic use of mesangial stem cells (MSCs) for tissue repair, including heart, has great potential. MSCs from multiple sources, including those derived from human umbilical matrix, namely Wharton's jelly, may serve as a resourceful candidate. Even after more than a decade, low engraftment efficacy of MSCs, in vivo, remains a limitation which requires in-depth understanding of the mechanisms and factors involved to facilitate a better and clinically relevant outcome. We recently hypothesized and demonstrated that the sex hormone – 17-beta estradiol (E2) – facilitates protective processes within the cardiovascular system by modulating MSC function, in vitro. Here, using a proteomic approach, we investigated the angiogenic potential of MSCs in vivo and the modulatory actions of E2 on mechanisms involved in tissue repair (potentially post-ischemic injury). Employing an in vivo approach with an ovariectomized (OVX) mice model, we evaluated the effects of E2 on MSC-induced angiogenesis using Matrigel plug assay. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-17 |
AnnouncementXML | Submission_2022-02-17_04:28:09.492.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD026380 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Felicia Antohe |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-05-31 07:14:50 | ID requested | |
⏵ 1 | 2022-02-17 04:28:10 | announced | |
Publication List
Mihai MC, Popa MA, Ș, uic, ă VI, Antohe F, Jackson EK, Leeners B, Simionescu M, Dubey RK, Proteomic Analysis of Estrogen-Mediated Enhancement of Mesenchymal Stem Cell-Induced Angiogenesis In Vivo. Cells, 10(9):(2021) [pubmed] |
Keyword List
submitter keyword: MSC, angiogeneis, proteomics |
Contact List
Felicia Antohe |
contact affiliation | Institute of Cellular Biology and Pathology |
contact email | felicia.antohe@icbp.ro |
lab head | |
Felicia Antohe |
contact affiliation | Institute of Cellular Biology and Pathology "N. Simionescu" |
contact email | felicia.antohe@icbp.ro |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026380
- Label: PRIDE project
- Name: Proteomic Analysis of Estrogen Mediated Enhancement of MSC-Induced Angiogenesis in vivo