PXD025002-2

PXD025002 is an original dataset announced via ProteomeXchange.

Title	The extracellular matrix landscape identifies different etiologies behind bicuspid and tricuspid aortic valve degeneration
Description	The molecular basis of aortic valve degeneration (AVD) is unclear. The extracellular matrix (ECM) of the valve is in dynamic reciprocity with its surrounding microenvironment and contains molecular traits of the pathophysiological processes. We compared abundances of ECM proteins from excised valve tissues of 88 patients with isolated AVD of normal tricuspid (TAV) and congenital bicuspid aortic valves (BAV) by employing a new method for protein preparation and quantitative mass-spectrometry analysis.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_06:53:26.797.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Beusch
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-25 07:07:23	ID requested
1	2023-09-03 13:36:43	announced
⏵ 2	2023-11-14 06:53:27	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: ECM,LC-MS/MS, Human, aortic valve degeneration, extracellular matrix

Sergey Rodin
contact affiliation	Department of Surgical Sciences Uppsala University 752 37 Uppsala, Sweden
contact email	sergey.rodin@surgsci.uu.se
lab head
Christian Beusch
contact affiliation	Division of Chemistry I Department of Medical Biochemistry & Biophysics Karolinska Institutet
contact email	christian.beusch@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD025002

PRIDE project URI

• PRIDE
  1. PXD025002
     1. Label: PRIDE project
     2. Name: The extracellular matrix landscape identifies different etiologies behind bicuspid and tricuspid aortic valve degeneration