PXD025002 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The extracellular matrix landscape identifies different etiologies behind bicuspid and tricuspid aortic valve degeneration |
Description | The molecular basis of aortic valve degeneration (AVD) is unclear. The extracellular matrix (ECM) of the valve is in dynamic reciprocity with its surrounding microenvironment and contains molecular traits of the pathophysiological processes. We compared abundances of ECM proteins from excised valve tissues of 88 patients with isolated AVD of normal tricuspid (TAV) and congenital bicuspid aortic valves (BAV) by employing a new method for protein preparation and quantitative mass-spectrometry analysis. |
HostingRepository | PRIDE |
AnnounceDate | 2023-09-03 |
AnnouncementXML | Submission_2023-09-03_13:36:43.454.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | ChristianBeusch |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-25 07:07:23 | ID requested | |
⏵ 1 | 2023-09-03 13:36:43 | announced | |
2 | 2023-11-14 06:53:27 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: ECM,LC-MS/MS, Human, aortic valve degeneration, extracellular matrix |
Contact List
SergeyRodin |
contact affiliation | Department of Surgical Sciences Uppsala University 752 37 Uppsala, Sweden |
contact email | sergey.rodin@surgsci.uu.se |
lab head | |
ChristianBeusch |
contact affiliation | Division of Chemistry I Department of Medical Biochemistry & Biophysics Karolinska Institutet |
contact email | christian.beusch@ki.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025002
- Label: PRIDE project
- Name: The extracellular matrix landscape identifies different etiologies behind bicuspid and tricuspid aortic valve degeneration